NURS 443 Lecture Notes - Lecture 1: Iron Deficiency, Immunodeficiency, Chromosome Abnormality
RNSG 2573: Concept: Cellular Regulation
Leukemia: group of malignant disorder affecting the blood and blood-forming tissues of the bone marrow, lymph system and spleen.
Lymphoma: malignant neoplasm originating in the bone marrow and lymphatic structures with proliferation of lymphocytes. 5th most common type of cancer in US
ALL
Acute lymphocytic
AML
Acute Myelogenous
CML
Chronic
myelogenous
CLL
Chronic lymphocytic
Hodgkin’s
Non-Hodgkin’s
Age of onset
Children: median age: 13
Most common leukemia
in children
Increases with age after
60
*Immature cells*
Most common
cancer in children 0-7
yrs
Increase with age
after 55
25% of all leukeia’s:
80% of adult acute
leukeia’s
Increase with age
after 55
Increase with age
after 50, greater in
men
Most common
leukemia in adults
*Mature cells,
abnormal*
15-35 and above 50
Men>women in
adults
Good long term
survival
Affecting all ages
5th leading cause of cancer
death
Assessment
See table 21-27 for data
Fever, lymphadenopathy, lethargy, pallor, purpura (easy bruising), tachycardia, murmurs, gingival
bleeding/hyperplasia, oral ulcers, hepatomegaly, sz, HA, disorientation decreased coordination,
bone or joint pain
B symptoms
correlate with a
worse prognosis:
initial findings of
fever (>100.4), night
sweats, and greater
than 10% wt loss in 6
months
Risk factors
Exposure to toxins, radiation, viruses, chromosome abnormalities leukeia: Dow’s sydroe,
immune deficiencies, organ transplants, prior cancer, family history
Some viruses, bacteria,
chemicals, inherited
immunodeficiency syndromes
and immunosuppressive
drugs.
Clinical manifestation
*leukeia’s: r/t bone
marrow failure and
formation of leukemic
infiltrates
Fever, pallor, bleeding,
anorexia,
fatigue/weakness. Bone,
joint, and abd pain.
General
lymphadenopathy,
infections, wt loss,
Fatigue/weakness,
HA, mouth sores,
anemia, bleeding,
fever, infection,
sternal tenderness,
gingival hyperplasia,
mild
No symptoms early in
disease. Fatigue and
weakness, fever,
sternal tenderness,
wt lost, joint pain,
bone pain, massive
splenomegaly,
Freq no symptoms.
Found during exam
for unrelated
condition. Chronic
fatigue, anorexia,
splenomegaly and
lymphadenopathy,
Enlarged cervical,
axillary, or inguinal
lymph nodes. Wt
loss, fatigue,
weakness, fever,
chills, tachycardia, or
night sweats.
May orginate outside lymph
nodes. Primary finding is
pailessl ymph node
enlargement that comes and
goes. . other symptoms based
on how wide spread:
hepatomegaly, CNS symtoms.
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Document Summary
Increase with age after 50, greater in men. Fever, lymphadenopathy, lethargy, pallor, purpura (easy bruising), tachycardia, murmurs, gingival bleeding/hyperplasia, oral ulcers, hepatomegaly, sz, ha, disorientation decreased coordination, bone or joint pain. Exposure to toxins, radiation, viruses, chromosome abnormalities (cid:894)leuke(cid:373)ia: dow(cid:374)"s sy(cid:374)dro(cid:373)e(cid:895), immune deficiencies, organ transplants, prior cancer, family history. B symptoms correlate with a worse prognosis: initial findings of fever (>100. 4), night sweats, and greater than 10% wt loss in 6 months. Leukemia: group of malignant disorder affecting the blood and blood-forming tissues of the bone marrow, lymph system and spleen. Lymphoma: malignant neoplasm originating in the bone marrow and lymphatic structures with proliferation of lymphocytes. 5th most common type of cancer in us. *leuke(cid:373)ia"s: r/t bone marrow failure and formation of leukemic infiltrates. Ha, mouth sores, anemia, bleeding, fever, infection, sternal tenderness, gingival hyperplasia, mild. Fatigue and weakness, fever, sternal tenderness, wt lost, joint pain, bone pain, massive splenomegaly, Wt loss, fatigue, weakness, fever, chills, tachycardia, or night sweats.
