HUBS192 Lecture Notes - Lecture 5: Basal Lamina, Tight Junction, Venule

• School: University of Otago
• Department: Human Body Systems
• Course: HUBS192
• Professor: Greg Jones

Document Summary

Thin walls: don"t" want a thick cellular barrier for exchange. Larger cross sectional area of capillary bed= greater rate of exchange. Differences in the cross sectional area of capillary bed and supply network makes blood flow slower/smoother. Textbookinfromation:despite having high numbers of capillaries inside the body, the capillaries themselves are not uniformly distributed. Body tissues such as liver/cardiac muscle, have high metabolic rates and require many capillaries. While tissues such as cartilage and epithelium are avascular and lack any capillary network altogether. Capillaries: the tube itself is made of cytoplasm of the endothelial cell; nucleus of the endothelial cell can also be observed; lumen of capillary: width of rbc; must travel one rbc at a time. Intercellular junctions (seal the tube off); the endothelial cell wraps around the tube and seal it off using intercellular junctions (mostly tight junctions); also forms junctions with cells upstream and downstream.