PHIL 2130 Lecture Notes - Lecture 16: Tight Junction, Fallopian Tube, Axoneme
6 May 2020
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Document Summary
Motile, finger like, beats in sync, used to move things. Axoneme subunit, consist of 9 dublets + 2 microbutules with associated protein. Anchoring junctions: mechanical strength: zonula adherens, macula adherens aka desmosomes, hemidesmosomes. Occluding junctions: permeability barrier: zonula occluden aka tight junction. Communication junctions: ionic/molecular movement from cell to cell: gap junctions. Anchoring cells to each other: mechanical strength and stability. Zonule = belt, link actin microfilaments of adjacent cells: cadheren: integral transmembrane linker glycoprotein ca2+ dependent, actin-binding proteins: connect cadherens to actin microfilament of cytoskeleton. Macula = spot, acts like a rivet. Links intermediate filament of network of adjacent cells. Role is to distribute cell stress: cadherens linked to intermediate filament via proteinaceous plaque. Integrins link intermediate filament network across basal cell membrane to basement membrane. Integrin proteinaceous plaque - intermediate filament. Used by motile non-epithelia cells like wbc. Integrins link to actin microfilaments, binds to fibronectin in basement membrane, subadjacent matrix.
