PHIL 2130 Lecture Notes - Lecture 17: Chemotaxis, Mast Cell, Eosinophil
6 May 2020
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Fibroblast, fixed macrophage, adipocyte, mesenchymal cells (multipotential stem cells) Wandering cells: increase number with tissue damage or infection. Free macrophage drawn by chemotactic signals, microphages(neutrophils and eosinophils. Lymphocytes: antibody producing plasma cells with antigen exposure. Fibroblast: produce fibres, proteoglycan and glycoproteins of matrix. Pale = active, darker when turn into fibrocytes, nucleus condenses. Plasma cells: derived from b-lymphocytes, antibody producing, basophilic cytoplasm filled rer. Mast cells: inflammation and hypersensitivity reaction, trauma or presence of antigen activation. Sensitization to specific antigens when antibodies made against antigen become bound again. Antibody primed mast cells by ige for second exposure, faster onset. Histamine: vasodilator, increase vascular permeability, increase production of protein-rich tissue fluid slows blood flow. Fat cells/adipocytes: lipid storing, dominant = adipose tissue. Macrophage: derived from blood monocytes, mature in tissue space, proliferate locally, phagocytic. Antigen presenting cells, identified by b cells. Kupffer cells in liver, microglial cells of cns, langerhans cells of ckin, osteoclast of bone tissue.
