PHIL 2015 Lecture Notes - Lecture 60: Liver Function Tests, Alcoholic Hepatitis, Glutathione
23 May 2020
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Document Summary
Due to affects flow and storage of free fatty acids in liver cells. If one keeps drinking at levels we talked about for several years, one will produce alcoholic hepatitis which shows infiltration with neutrophils, lymphocytes, inflammatory cells. The patient is much sicker, and present to hospital with upper right quadrant pain and can have jaundice. Pentoxifylline (drug) approved for people with peripheral vascular disease, but found to be an inhibitor of tumor necrosis factor which is a cytokine that leads to damage in liver alcohol disease, potential new role of this drug. Patient survives alcoholic hepatitis and keeps drinking =cirrhosis. Blue tissue=collagen or fibrotic tissue that is non functioning a lot of hepatocytes replaced with fibrotic tissue. Fibrosis may regress, but nodules tend to stay out of form and surrounded by fibrous tissue even if stop alcohol. Active cirroshis=contineu to drink, liver disease progressing, liver function tests are abnormal this is active cirrhosis.
