NATS 1670 Lecture Notes - Lecture 1: Bacterial Conjugation, Neisseria, Antimicrobial Resistance
8 Jan 2018
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Arise in bacterial population spontaneously or induced (cancer treatment radiation & some. Exchange of genetic information in bacteria chemo) However, bacteria are haploid rapid growth rate, selective advantage enriches for mutants and sisters) donor cell contributes part of its genome (not all) recipient cell; unidirectional. Horizontal gene transfer: acquiring genes from other microbes of the same generation (brothers (donor to recipient); can occur between species. Cells that take up dna are competent (ie. streptococcus, haemophilus, neisseria, bacillus, staphylococcus and pseudomonas) results from an alteration in the cell wall/cytoplasmic membrane that allows dna to enter cell. Infection of donor: assembly of phages particles, release of phage. Gene transfer from donor recipient by direct physical contact between cells. Mating types in bacteria donor has f factor in pili, recipient lacks f factor. Donor cell attaches to recipient with its pilus, 2. F+ cell with a pilus; donor synthesizes a complementary strand, restoring its complete plasmid. Clinical significance of transformation, conjugation and transduction.
