KINE 2475 Lecture Notes - Lecture 41: Hirsutism, Globulin, Dysmenorrhea

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Etiology & pathophysiology: menstrual cycle comprises of 3 phases, follicular, ovulatory, luteal. Follicular phase continues until ovulation --> day 14: day 1 of menstrual cycle is first day of menses (period). Marks start of follicular phase: time after ovulation is luteal phae --> lasts until beginning of next menstrual cycle, hormonal relationship amount-> hypothalamus, anterior pituitary & ovaries, hypothalamus secretes gnrh --> stimulates anterior pituitary to secrete. Fsh & lh --> stimulate production of fertile ovum in ovaries. Fsh allows one follicle to enlarge & produce estradiol, progesterone: estradiol stops menstrual flow, thicken endometrial lining of uterus to prep for embryonic implantation. Fsh regulates aromatase enzymes that converts androgens to estrogens in follicle. Ovulation: when estradiol levels remain elevated for a while, it results in lh surge, oocyte is released & travels to fallopian tube. It can be fertilized & transported to uterus. Lh surge results in follicular rupture & release of oocyte.

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