KINE 2475 Lecture Notes - Lecture 11: Glucose-6-Phosphate Dehydrogenase Deficiency, Vicia Faba, Lactic Acidosis
13 Jan 2020
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Genetic disorders of erythrocytes: genetic & environmental causes of glucose 6- phosphate dehydrogenase (g6pd) deficiency, abnormal hemoglobins (hbs & thalassemia"s) Genetic g6pd deficiency: g6pd deficiency is x-linked, g6pd is necessary to produce nadph. If low levels of nadph cannot fight superoxide radicals. G6pd deficiency & malaria: large populations evolved to have g6pd deficiency. Individuals w/normal levels of g6pd die w/malaria infections. Individuals w/low levels of g6pd activity have greater chancer of survival w/infections. Infected rbcs still have dna/rna, blood spears you see inclusions. How g6pd deficiency combats malaria: low g6pd enzyme low nadph lower gsh:gssg ratio in cells higher levels of. Dietary g6pd deficiency: vicine is found in uncooked fava bean, vicine is toxic glycoside that increases body"s need for nadph & strains gsh stores low ph (stomach), vicine cleaved to glucose & divicine (oxidized form). Divicine is then reduced: divicine undergoes reactive cycling which creates ros, ros toxicity cause hemolytic anemia.
