KINE 2475 Lecture Notes - Lecture 1: Thyrotropin Receptor, Anterior Pituitary, Follicular Cell
13 Jan 2020
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Introduction: how they thyroid, hypothalamus, pituitary gland & thyroid axis affect each other, hypothalamus involved in detecting: hunger, sleep, thirst. It links nervous system to endocrine system via pituitary gland. Regulates certain metabolic process & other activities of ans. It synthesizes releasing hormones: thyroid axis- trh (hypothalamus) -> tsh (pituitary gland) -> t3/t3 (thyroid gland, thyroid secretes more t4 & less t3. Most t3 is generated by peripheral conversion of t4. Features of thyroid gland: thyroid organ is important in regulating body metabolism, highly vascular tissue, feel smooth/solid, thyroid dysfunction reduces effectiveness of antidepressants, goiter is enlargement of thyroid gland. Caused by iodine deficiency, autoimmune deficiency like hashimoto"s thyroiditis & graves" disease, hyperthyroidism, hypothyroidism, thyroid cancer, inflammation: follicular cells aka thyroid cells are responsible for production and secretion of thyroid hormones. Colloid stored thyroglobulin- its amber in color because its basic- eosin) Follicle cells synthesize thyroglobulin & secreted it into lumen for iodination & storage.
