KINE 2011 Lecture Notes - Lecture 12: Tetrodotoxin, Malignant Hyperthermia, Ryanodine
17 Sep 2017
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At the exact same time, there is pumps puling calcium back into the sarcoplasmic reticulum. For every stroke inwards, we generate more tension, the only problem is action potential is automatic. Immediately after the action potential has induce the release of calcium, the sarcoplasmic reticulum starts to pump it back: calcium cytosolic concentration declines, some of the troponin-tropomyosin complexes slip back into their blocking position. Length of contraction depends on how long calcium is available. If there is only one action potential, calcium is always getting pumped into sr, no more calcium leaking out. If there are two close by, same things happen. But before you are back to resting amount of calcium, another action potential comes through (more calcium comes flooding out) and cross-bridge cycle continues. Now you can increase tension that is generated. If you put action potential close by, you can get maximum force generation.
