BIOL 4310 Lecture Notes - Lecture 17: Advanced Sleep Phase Disorder, Circadian Clock, Arntl
31 Mar 2020
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Lecture 17 march 17 circadian clocks and the genetics of sleep disorders. Also allows us to help individuals not getting enough sleep. Circadian clock = internal self-sustaining oscillator that organizes our bodies activities around a 24 hour day (incl sleep-wake cycle, which can be affected if our clock is misaligned) Process s - sleep debt, increase during activity (subjective day) and decreases during sleep. Dep on time of onset, may sleep for more or less time. Ttfl: clock + bmal1 form complex that bind e-box and activate transcription of per1, per2, cry1, cry2 and rev-erb . Per1/per2/cry1/cry2 proteins form a complex that inhibits the clock-bmal1 complex from activating the transcription of the 5 target genes. Rev-erb inhibits bmal1 transcription: ck1 phosphorylates and degrades the per proteins in the cytoplasm. The cry proteins can then bind to that ck1-per complex and prevent further degradation go to nucleus to cause inhibition: fbxl3 f-box protein degrade cry1/2 in cytoplasm.
