BIOL 3155 Lecture 5: BIOL 3155 Lecture 5.docx
29 Jan 2015
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Midterm #1 thursday february 4th (5:30 - 6:50 pm) vari hall b: material up until and including thursday january 28th. Cell invasion: can"t fuse with membrane because no envelope, therefore need to go in by endcytosis (eg. adenovirus) Nc release: virus progresses along with endosome and in order for nc to be released into the cytosol the endosome needs to rupture. January 21, 2010: release of genetic information which can occur during or after rupture. Cell invasion: option #1 - fuse with cell membrane and loses its envelope in the process (eg. herpes simplex virus hsv, option #2 endocytosis virus maintains its envelope (e. influenza virus) Release process that can be equated to fusion. During the initial fusion event with the cell membrane the nc is released at the same time couples steps 2 and 3: option #2 (above) Viruses that invade by cell fusion require a second fusion event where the. Nc leaves the endosome and enters the cytosol.
