BIOL 3120 Lecture Notes - Lecture 4: Complement Membrane Attack Complex, Complement System, Complement Receptor
Document Summary
Part of the inflammatory response is to increase leakage of fluid from the blood with the dissolved proteins in it (still needs activation: the complement system is composed of many molecules that fall into 7 categories: Prrs to trigger phagocytosis: anaphylatoxins: trigger more inflammation, membrane attack complex: forms holes in membrane of pathogen, complement receptors: detect and respond to complement, on cell surfaces (white blood cells or cells that can respond and detect complement) C# = inactive form cleavage c#b = big piece and c#a = small piece: during the pathways, enzymatic molecules are activated to further activate the complement molecules. The classical pathway: initiation is done by c1 complex (a molecule), but it only initiates when it binds to an antibody in the right configuration. There are 5 types of ig and a few subtypes: igg, igm, igd, ige, Igg: secreted as a monomer, needs to or more to trigger complement. So that the system is no accidentally triggered.
