BIOL 3051 Lecture Notes - Lecture 22: Transferrin Receptor, Iron Overload, Hepcidin
20 Apr 2020
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Increased rbcs production- decreased hepcidin: low dietary iron, low body iron stores decreased hepcidin produced, low hemoglobin, low blood oxygen content low hepcidin. Low rbc production can be due to increase fe- problematic. Condition which decrease iron absorption: systemic inflammation leading to increase hepcidin production, don"t want bacteria to utilize fe. Iron protein, ferritin: mw 450,000; primary role in iron storage (liver, 24 x 175 aa (18. 5 kda) complex, holds 4500 fe(oh)3. Holds lots of iron, fe vault: present in various places in body in numerous cells: gut mucosa, lover, blood plasma. If ferritin were fully saturated, it would hold 4500 fe level: diagnostic tool available to determine ferritin & blood saturation levels. %fe load of ferritin is a diagnostic tool. Normally a low level of ferritin present in human plasma. Iron released from ferritin by reduction & chelation: ferritin internalized via ferritin receptor, alcoholism/hepatitis (damage to liver/hepatocyte): decreased transferrin-bound iron.
