BIOL 3051 Lecture Notes - Lecture 14: Rheumatoid Arthritis, Calcium Channel Blocker, Heart Failure
20 Apr 2020
School
Department
Course
Professor
Document Summary
Current medication (pink for heart, grey for rheumatoid arthritis): Cox1 inhibition and produces anti- thrombotic effects to prevent excess blood clots. Block beta1- adrenergic receptors found in the heart, lowering camp production, causing relaxation of vasculature. Side effects include ulcers, dyspepsia, heartburn, epigastric distress, nausea, vomiting, and diarrhea. Side effects can be avoided by taking with food and using ec formulation (as they are). Acei, acetazolamide (increase serum conc. causing confusion), anticoagulants can increase risk of bleeding, and large doses of asa can decrease blood glucose so monitoring levels of. Watch use with antiplatelet agents for risk of bleeding, calcium channels blockers increase bleed times, and corticosteroids will decrease the serum salicylate levels. With use of methotrexate (common rheumatoid arthritis front line med) can cause increase in methotrexate levels and lead to cytotoxicity. Ssris alter platelet function and are associated with increased bleeding risk in patients on.
