BIOL 3051 Lecture Notes - Lecture 3: Inflammatory Arthritis, Hyperuricemia, Coronary Artery Disease
20 Apr 2020
School
Department
Course
Professor
Document Summary
What is gout: gout is disease where monosodium urate monohydrate (msu) crystal deposit in joints, soft tissues (cartilage, tendon, bursa) or renal tissue (glomeruli, interstistium, tubules), results in tophi, neuropathy, uric acid nephrolithiasis. Its most common inflammatory arthritis in men older than 40 years. Goals of therapy: terminate acute attack of arthritis, prevent recurrences, prevent or reverse complications, treat association disorders. 4 stages of gouty arthritis: asymptomatic hyperuricemia, acute gouty arthritis, intercritical period (prophylaxis & management, of hyperuricemia, chronic tophaceous gout. Hyperuricemia: alcohol, cyclosporine, cytotoxic chemo, diuretics (thiazide, loop, levodopa, niacin, salicylates, tacrolimus, atherosclerosis, chronic kidney, glomerular, renal disease, diabetes, hyperlipidemia, hypertension, ischemic heart disease, lead intoxication, metabolic syndrome, obesity, diet. Pharmacologic choices: nsaids, colchicine or oral corticosteroids are first-line options. Should be initiated within first 24 hrs of acute gout attack onset: colchicine: initially 1. 2mg is given, then 0. 6 mg 1 hr later.
