BIOL 3051 Lecture Notes - Lecture 6: Arthralgia, Hyaline Cartilage, Insulin Analog
20 Apr 2020
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Reports of arthralgia have occurred with numerous drugs; however, the numbers are small and often a cause-and-effect relationship cannot be clearly established. Recombinant human insulin analogue (parenteral) for t1dm (well-managed) Ppi (gastric acid secretion) for gastric ulcer (well-managed) Nonselective nsaid (cox-1/2, reversible) for s&s of oa. Rare (<1%) arthralgia and arthritis; time frame inconsistent. Presumably started 6 m ago (d/c 6 w ago) Rare (<1%) arthralgia and osteoarthritis; time frame inconsistent. Highly unlikely; time frame inconsistent; now d/c yet still have oa. Osteoarthritis is the most common form of arthritis, is a disease of diarthrodial joints (typically spine, hands, hips, knees), involving the progressive destruction of articular cartilage. No physical exam or x-ray data to confirm. Herberden"s nodes + bouchard"s nodes: hard bony growths on the finger/toe joints (distal + proximal, respectively) not usually tender upon touch. X-rays to establish the presence/extent of damage narrowing of the joint space. Ethnicity (not a risk factor but a trend)
