BIOL 2060 Lecture Notes - Lecture 13: Hematuria, Hemolytic Anemia, Stercobilinogen

• School: York University
• Department: Biology
• Course: BIOL 2060
• Professor: Hernan Humana

Document Summary

Urobilinogen: hemoglobin broken down, non-iron portion of heme converted to bilirubin, bilirubin released in bile ducts- secreted to small intestine as bile, in si, bilirubin metabolized to urobilinogen. Bilirubin urobilinogen in small intestine: two fates of urobilinogen, remains in intestine. Gives brown fecal colour: urobilinogen absorbed to blood from intestines. From liver diverted back to si as bile. Fraction filtered by glomerular & excreted by urine. Cycling of urobilinogen b/t liver & intestines called enterophepatic urobilinogen cycle. Diseases cause alteration of urine urobilinogen levels. More hb broken, more bilirubin produced, more urobilinogen in intestines & reabsorbed. More urobilinogen gets filtered from blood when it reaches kidney to be returned to liver. Disease of liver like cirrhosis & hepatitis: gives excess urob in urine. More urob remains in circulation in liver & thus more to kidney to be excreted. Non-iron heme bilirubin (bile ducts) urobilinogen (small intestine) sterocobillnogen (intestine) stercobilin (feces brown colour)