BIOL 2021 Lecture Notes - Lecture 4: Antiporter, Atp Synthase, Drug Resistance
26 Jan 2017
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S(cid:373)all , (cid:272)harged or polar thi(cid:374)gs do(cid:374)"t go through. Fig 11-1 shows that bilayer is permeable to small and nonpolar molecules. Solution depends on the size of the cargo (cargo is the thing you want to transport) Large particles, cells (sometimes cell transport other cells inside of them) Protein translocators - complex proteins might need a nuclear pore (chpt 12) Endocytosis, phagocytosis (chpt13) ion concentrations on right (know this) Not much of a ph gradient so we can ignore it and say that everywhere its about ph 7: cl- is high outside and low inside. Membrane potential: comparing the inside of the cell from the outside. 20mv to -150 mv depending on the cell: meaning that there is an excess of negative charge on the inside. We need energy to do work table 11-4b. Has two parts: electric gradient charge difference, chemical gradient concentration difference. Work required to move something across a membrane depends on concentration gradient + electrical gradient.
