BIOL 2020 Lecture Notes - Lecture 8: Zymogen, Chymotrypsin, Histidine
Document Summary
Announcements: midterm on october 7th writing in vh a 8:30am. Last time we talked about kinetic constants, mm equation, km (michaelis constant) is the value where when the km = [s], initial velocity = vmax (constant with specific reaction) Km = [s] v0 = vmax o: for km > [s], at this point enzyme concentration > substrate concentration, at low [s] you see rapid increase in rate of rxn. First order region: levels off at zero order. Inhibitors can be reversible or non reversible combine and dissociate from enzyme. Today we focus on reversible i. e drugs: e + i ei. Common types of inhibition are: competitive inhibition, noncompetitive . [i] if [i] > [s] you get ei complex and inhibition if [i] < [s] you get the es complex and rxn: they compete for the same spot o, infinite [s] means no inhibition and rxn proceeds.
