BIOL 1000 Lecture Notes - Lecture 8: Nucleoid, Nucleolus, Deoxyribose
24 Jan 2017
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Major groove: where dna binding proteins bind to bases in major groove. Bases in dna are stacked in same plane = from hydrophobic interactions: its not just attraction of bases but the hydrophobic interaction, bases are trying to get away from the water and come together. The distance between 2 bases is 0. 34nm. Most energetically stabled favoured form: = aka b form. A transcription factor, histone, are things that bind in the major groove. Unshared electron pair between hydrogen and more electro negative atom (ability to attract electrons to its nucleus: i. e: o2 and hydrogen. Electron pair would be closer to oxygen nucleus than hydrogen nucleus. The oxygen is more negative and the hydrogen is positive: this creates a gradient of charge. This is an example of a dipole. Keto structure (hydrogen acceptors) and hydrogen donor (hydroxyl) has a weak: can make weak attraction to something else attraction, covalent bonds are strong and can"t be broken easy.
