PS365 Lecture 10: Psychiatric and Related Disorders
Document Summary
The brain and behaviour: overwhelming evidence that psychiatric or behavioural disorders have a biochemical, anatomical, experimental, or genetic basis, this is not the case in pre-scientific societies where superstition abounds, e. g. Mood disorders: clinical depression, prolonged feelings of worthlessness and guilt, general slowing of behavioural output, disruption of eating and sleeping, mania, excessive euphoria, hyperactivity, bipolar disorder, periods of depression and mania. The hpa axis: tress sig(cid:374)al (cid:894)e. g. (cid:271)ei(cid:374)g atta(cid:272)ked (cid:895) Immediately release (via hypothalamus) corticotrophin releasing hormone, influences the anterior pituitary gland, which releases acth: acth affects adrenal gland and kidney, releases cortisol, deactivation feedback loop gets rid of (cid:272)ortisol. Neuropathological and blood flow (fmri) abnormalities in depression: decreased activity in, dorsolateral and medial prefrontal regions, reduced memory and attention. Anxiety disorders: panic disorder, gad, ocd, phobias, ptsd, common thread through all is fear, drug therapy: anxiolytics. Cortical thickness and ptsd: those (cid:449)ith pt d ha(cid:448)e thi(cid:374)(cid:374)er regio(cid:374)s of fro(cid:374)tal (cid:272)orte(cid:454) .
