PS280 Lecture Notes - Lecture 9: Twin, Prefrontal Cortex, Antipsychotic
Document Summary
Adoption studies: 17% of children adopted from mothers with. Most support for polygenic models; a combination of several genes that increase risk schizophrenia. Excess of dopamine that is responsible (d2 receptors) Dopamine blocked right away, but can take time for therapeutic. Dopamine antagonists work better on positive symptoms psychotic symptoms. Ventricle enlargement; but not true for every person with schizophrenia. Prefrontal cortex: hypofrontality; less activity in the prefrontal cortex. Etiology- non biology: social class, expressed emotion (ee) Environment with criticism, hostility, and emotional over involvement. Treatment: early forms of treatment; not used today anymore, antipsychotic drugs (neuroleptics, atypical antipsychotics (ex clozapine, psychosocial interventions, cbt study example. Psychotherapy; focused therapy + medication + housing mouth, jaw, etc. Tardive dyskinesia: involuntary movement of the face, tongue, Issue of compliance: directly related to the significant side activity effects. Routine care vs routine care + cbt vs routine care + supportive counselling. Same symptoms as schizophrenia but <6 months and impaired.
