BI226 Lecture 2: BI226 - Lecture 3 (Autosaved)
Document Summary
Genes on dna are transcribed to rna which can then be translated to protein the central dogma of biology. Garrod (1902) proposed that mutations prevent a gene from producing an enzyme required for a specific biochemical rxn. Showed that alkaptonuria results from homogentisic acid(ha: lack caused by mutation. Prevents conversion of phenylalanine into tyrosine: phenylalanine is an essential amino acid. In excess harmful normally converted to tyrosine. Excess phenyl, affects the cns, causing mental retardation, slow growth, early death. Drop of blood on filter paper is placed on solid media containing beta 1 and bacterium bacillus subtilis. Results from autosomal recessive mutation in the gene tyrosinase. Rna polymerase transcribes dna to produce an rna transcript. Ribosomes translate the mrna sequence to synthesize a polypeptide. Downstream, #1 has to be the last in the pathway, downstream will grow, upstream it will not grow triplet codon on test** Correlation of polarities in dna, mrna and polypeptide.
