BI110 Lecture Notes - Lecture 11: Aminoacyl Trna Synthetase, Reading Frame, Transfer Rna
Document Summary
Translation: primary structure is the sequence of amino acids, secondary structure results from interactions of nearby amino acids, tertiary structure is the 3-dimentional shape of a polypeptide, quaternary structure results from interactions of polypeptide subunits. Translation: mrna to protein, components of translation, messenger rna (mrna, initiation factors, elongation factors, release factors, aminoacyl trna synthetases, transfer rna (trna, ribosomes (ribosomal rna + ribosomal proteins) Eukaryotic translation initiation: monocistronic mrna, encode one polypeptide for one mrna molecule. Initiation at 5" cap; them complex scans for first aug: amino group is where initiation, part that we end is carboxyl group. Prokaryotic translation initiation: polycistronic mrna, mrna can therefore code for several polypeptides. Initiation factors recruit the small ribosomal subunit and trna met to the 5" cap and scan the mrna for an aug codon. A new trna complementary to the next codon binds to the a site.
