Psychology 2310A/B Lecture 9: Lecture 9; personality disorders.docx

• School: Western University
• Department: Psychology
• Course: Psychology 2310A/B
• Professor: Rod Martin

Document Summary

Dopamine is involved in: movement, cognition (memory, attention, problem solving), motivation and pleasure, sociability. Nigrostriatal substantia nigra, basal ganglia (parkinson"s disease) D2 receptors positive symptoms (delusions, hallucinations) benefit from antipsychotics. D1 receptors negative symptoms inadequate receptor binding. Effects of drugs that increase dopamine (amphetamines, cocaine, l-dopa) Cortical atrophy esp. frontal lobes, also temporal lobes, basal ganglia. Frontal lobe (hypofrontality) executive functions, avolition, personality change, working memory. Left temporal lobe thought disorder, bizarre language, memory, selective attention. Right temporal lobe flat affect, aprosodia, poor discrimination of facial emotion. Basal ganglia abnormal motor behavior rocking, pacing, stereotyped movements. Traditional antipsychotics 1950s & 60s e. g. , chlorpromazine, haloperidol. Atypical antipsychotics 1990s e. g. , clozapine, risperidone, olanzapine. But still do not cure the disorder high relapse rates. Weight gain, anxiety, insomnia, dry mouth, constipation, low blood pressure, sexual dysfunction. Enduring pattern of inner experience and behaviour that deviates markedly from cultural norms. Manifested in 2 or more areas: cognition, affectivity, interpersonal functioning, impulse control.