Physiology 4700A/B Lecture Notes - Lecture 11: Amyloid Precursor Protein, Neurofibrillary Tangle, Amyloid
22 Apr 2019
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Alzheimer"s disease, cognitive impairment and white matter inflammation. By the year 2050, the prevalence of ad will double. This is largely due to the aging demographic. Forgetfulness with effects at work (ex: forgetting names that are personal to you can be an indication that there is cognitive impairments) Impaired capacity of judgement (appropriate clothing: ex: wearing bathing suit in winter, ex: putting an iron in the fridge d. Mood swings and behavioral changes (sudden changes) If you were to take an ad patient and they pass away and you remove the brain to look histologically at what is going on in the brain. We also know that the amyloid pathway and the change associated with the ad elicit a strong inflammatory response recall: there are diff types of glial cells that are associated with inflammation (mainly astrocytes and microglia) Nfkappab will activate the transcription of downstream cytokines called tumor necrosis factor alpha (tnfalpha) or interleukin1beta (il-1beta)
