Physiology 4700A/B Lecture Notes - Lecture 8: Chromatin, Lac Operon, Chromatin Immunoprecipitation
Document Summary
Greater incidence of preterm birth as time progresses, maybe due to more frequent in vitro fertilizations which lead to more twins o. Leads to greater incidence of low bw --> barker"s. Long term costs: with long term diseases such as asthma, and adult onset diseases: metabolic diseases, cvd. Driven by inflammation: which also plays a major role in diseases: cancer, cvd, alz, t2d, arthritis, autoimmune, neurological, pulmonary. Cooordinated contraction of fundal myometrium and lower uterine segment myometrium facilitates labour o o o. Fm: origin of contractility (contracts first), where head resides; Inflammation occurs at fm first since fm has to contract first. Increased levels of il-1 in amniotic fluid and macrophages in the myometrium in labour. For pre-term labour, it"s b/c of a bacterial infection that provides the stimulus for il-1/macrophages. Determining if macrophages in pregnant uterus at term are of fetal origin.