Physiology 4600A/B Lecture Notes - Lecture 2: Inhibitory Postsynaptic Potential, Metabotropic Receptor, Ligand-Gated Ion Channel
15 May 2019
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Main neuronal inhibition in cerebral cortex & brain (esp. in forebrain in cortex) Gaba receptors can be type a or b. Measure the action of gaba by looking postsynpatically (look at ipsps: recording is approx. 100ms: late component depends on gaba b being present or not, early component is attributed to gaba a. Inhibitory postsynaptic potential has early and late components. Different experimental approaches are used to study epilepsy and seizures. In vivo: in animals, using induced seizures or epilepsy in animals: can have chronic or acute models of epilepsy. Partial seizure acute models (in vitro or in vivo) Inhibitory (gaba a) receptor antagonist: bicuculline, picrotoxin induce epileptic activity. Excitatory agonist: glutamate agonist to induce seizures: kainate, nmda, ibotenic acid, acetylcholine agonist: pilocarpine (induce seizure at high dose, acetylcholinesterase inhibitor prevents the hydrolysis of ach = can induce seizure by increase [ach] in the brain. K+ channel antagonist that can induce seizure: 4-aminopyridine.
