Physiology 4530A/B Lecture Notes - Lecture 4: Collagen, Chondrogenesis, Type Ii Collagen

• School: Western University
• Department: Physiology
• Course: Physiology 4530A/B
• Professor: Frank Beier

Document Summary

Both of these are acute problems and associated w developmental problems in bone formation. Vertebrae: 7 cervical, 12 thoracic, 5 lumbar, 9 sacral + coccyx. Spinous process: pointed muscle attachment point tethering muscles extending dorsal/caudal; protects spinal cord. Superior/inferior articular processes: forms facet joints with adjacent vertebrae via articular facets. Spinal canal: contains spinal cord from brain stem to upper lumbar, terminating at conus medullaris (which has the cauda equina (bundle of nerves) branching off here; nerve roots are suspended in dural sac) Motion segment: 2 vertebrae and ivd and 2 facet joints. Cartilaginous joints consisting of connective tissue anchoring adjacent vertebrae (no synovial fluid) Absorbs compressive load; allows flexibility/mobility of spine: tensile and compressive stresses on disc increases in magnitude down spine because of body weight and geometry of spine. Nucleus pulposus: gelatinous matrix of pgs (aggrecan) and type ii collagen. High pgs (so high h2o), low collagen.