Physiology 3140A Lecture Notes - Lecture 1: Lipid Droplet, Intermediate Filament, Nuclear Membrane
2 May 2018
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Cellular Physiology 3140 Lecture 1
September 8 2017
What is Cell Physiology?
- Study of how cells work together to perform functions in a living organism
o Genetics, Cell Biology, Biochemistry, etc.
o Communication
▪ Cell to cell
▪ Intracellular communication – membrane to nucleus so nucleus can respond to
what is happening on the outside of the cell
- Membrane transport – how things get in and out of the cell
The Average Cell
- High complexity in the cell
- Nucleus strengthened by nuclear membrane proteins (ex. lamin)
- What’s missing?
o Centrioles
o Bilayer
o Ribosome
o Vesicles
o Cytoskeleton – actin, microtubules, intermediate filaments, etc.
o Specialized organelles – lipid droplet, nucleosos, peroxisome, etc.
o Cell attachment – focal adhesions, etc.
o Etc.
What would be a reasonable analogy of the intracellular environment of a cell?
- Super packed environment
- Makes proteins and has to send them to where they want to be – so they can interact with other
proteins
Reality of cells
- Packed environments
o Issues with molecules finding each other
▪ Once they find each other – you are being pushed into the other molecule because
its so packed
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Document Summary
Study of how cells work together to perform functions in a living organism: genetics, cell biology, biochemistry, etc, communication, cell to cell. Intracellular communication membrane to nucleus so nucleus can respond to what is happening on the outside of the cell. Membrane transport how things get in and out of the cell. Nucleus strengthened by nuclear membrane proteins (ex. lamin) What"s missing: centrioles, bilayer, ribosome, vesicles, cytoskeleton actin, microtubules, intermediate filaments, etc, specialized organelles lipid droplet, nucleosos, peroxisome, etc, cell attachment focal adhesions, etc, etc. proteins. Makes proteins and has to send them to where they want to be so they can interact with other: once they find each other you are being pushed into the other molecule because. Packed environments its so packed: easy to maintain in contact because its crowded, solved by compartmentalization (by membranes), guided signaling, microdomains of.
