Physiology 3140A Lecture Notes - Lecture 30: Barr Body, Protein Isoform, Dicer

• School: Western University
• Department: Physiology
• Course: Physiology 3140A
• Professor: John Di Guglielmo

Document Summary

Affect transcription, silence genomic regions or alter rna processing all leading to changes in rna accumulation and expression. Regulating expression of gene but in a process of not mutating the genes (not causing deletions or changes in the dna sequences) Known protein coding gene exons compose less than 3% of the human genome. Based on the encode* database, approximately 76% of the human genome is transcribed: rna transcrips were being made but were not giving rise to protein, = non coding rnas. Most of these transcripts do not code for protein called non-coding rnas (ncrnas) Separated into two classes: short ncrnas: most of them are in this class, less than 200 bp, long ncrnas. Long ncrnas are arbitrarily defined as being longer than 200 nucleotides. Non-coding rnas: some are consistent throughout but there are a lot of differences: like normal protein coding, there is very specific expression patterns during development and in disease processes.