Physiology 3140A Lecture Notes - Lecture 9: Cleavage Furrow, Sarcomere, Ultimate Tensile Strength

• School: Western University
• Department: Physiology
• Course: Physiology 3140A
• Professor: John Di Guglielmo

Document Summary

Network of protein fibers that extend throughout the cytoplasm. Nomenclature is based on size of the structure that it takes. Vimentin: if and a good marker for mesenchymal cells. Desmin: desmosomes attached to if within the intercalated disks of the heart. Nuclear lamins: found in the nuclear membrane and not the same as laminin: laminopathies: ecm makes a signal all the way into the nucleus. Made of polymer of and b tubulin dimer (basic subunit: subunits come together to form protofilaments, protofilaments come together to form a hollow tube (mt) Gtp-binding subunits come together in protofilaments (lines) to form hollow tubes: both alpha and beta tubulin are gtp bound and as mt grows, the gtp is cleaved on the beta subunit to gdp. Dynamic instability: balance between assembly (polymerization) and disassembly (catastrophe) and reassembly (rescue, dependent on subunit critical concentration and temperature, dependent on gtp-b-tubulin cap.