Physiology 3140A Lecture Notes - Lecture 2: Tata-Binding Protein, Transcription Factor Ii B, Green Fluorescent Protein
3 Dec 2016
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Why does progeria not affect the cns: lmna gene affected is not expressed in neurons. How are the nls signatures different: recognize different regions of importin- , recognize different importin- isoforms, recognize directly by specific receptors of the importin- family without the intervention of an importin -like protein. Transcription: makeup of the genome, promoters and enhancers, general transcription factors, genome organization, transcription factor families, regulation of transcription factors. Tell the ge(cid:374)e (cid:862)whe(cid:374)(cid:863), (cid:862)where(cid:863), a(cid:374)d (cid:862)how (cid:373)uch(cid:863) they"re goi(cid:374)g to (cid:373)ake. Pre-mrna is transient: before it is fully made, splicing is occurring to make the mature rna. Utr is not important for coding region but have important fc(cid:495)n in which things. Enhancers can be anywhere in the genome and affect any gene (cid:523)don(cid:495)t have to be. Position is fixed upstream (cid:523)(cid:887)(cid:495)(cid:524) of the transcriptional start site (cid:523)tss(cid:524) (+1) Contains the consensus dna sequences tata/caat (-35: ~(cid:885)(cid:882)% of genes don(cid:495)t have the tata box.
