Physiology 3140A Lecture Notes - Lecture 5: Creb, Adenylyl Cyclase, Glycogen Phosphorylase

• School: Western University
• Department: Physiology
• Course: Physiology 3140A
• Professor: Donglin Bai

Document Summary

Adenylate cyclase (ac) is a plasma membrane bound enzyme it cleaves the two terminal phosphates and cyclizes the last phosphate, making a monophosphate product. Adenylate cyclase is activated when the cell has high [atp] and low [amp], or by gpcr signalling. (cid:272)amp is degraded to 5"-amp by cyclic amp specific phosphodiesterase. Adenylate cyclase consists of two alternating hydrophobic and hydrophilic domains. The hydrophobic domains each contain 6 membrane spanning domains and the hydrophilic regions have two catalytic domains. There are multiple isoforms of adenylate cyclase, all of which can be stimulated by gs and inhibited by gi camp acts as a signalling molecule and functions as an intracellular messenger. Its primary physiological function is to serve as a second messenger intracellularly and bind protein kinase a (pka). It also acts as a ligand for a specific class of odorant cation channels in the olfactory neurons.