Physiology 3120 Lecture Notes - Lecture 7: Electrochemical Gradient, Neuron, Abdominal Pain
14 Mar 2018
School
Department
Course
Professor
Document Summary
A patient is seen in an emergency room complaining of numbness in the lips and mouth with profuse salivation. The person also has a severe headache with sweating and weakness in the limbs. They have also had severe nausea, vomiting and abdominal pain. Earlier in the day they ate at a restaurant where they had raw puffer fish. Puffer fish is known to contain tetrodotoxin (ttx) a powerful neurotoxin which reversibly blocks na+ voltage gated channels. Na+ v. g channels are affected by: grayanotoxin, mad honey, blocks inactivation gate, membrane will stay in a depolarized state, have lots of seizures. K+ v. g channels inhibited by: tetraethylammonium (tea, dendrotoxin from mamba snake. Changes in na+ and k+ conductance (ec 60) Conductance has to do with the movement of the ion across the membrane. This image shows you when the channels are opening and closing. Not all na+ vg channels open at once.
