Physiology 3120 Lecture Notes - Lecture 7: Tandem Pore Domain Potassium Channel, Hyperkalemia, Collecting Duct System

• School: Western University
• Department: Physiology
• Course: Physiology 3120
• Professor: Tom Stavraky

Document Summary

Also increased/decreased anp + raas pathway during these responses. Sweat is the removal of hypo-osmotic fluid from the body. Adh is released from pituitary: increased plasma osmolarity, decreased ecf volume. Macula densa cells are not activated here (due to increase in na+ conc more than normal: 2 of the stimuli for renin release is present and 1 is absent. Increase sodium reabsorption further improves water reabsorption via osmosis. Maximizing water conservation (1) increased water balance normal ecf volume turn off raas pathway. Adh release continues increased water reabsorption continues (2) increase sodium/osmolarity balance (from sodium reabsorption due to raas) homeostasis. ** have to balance both water and osmolarity body balances water first and osmolarity follows. The kidneys is one of the three mechanisms that body uses to balance acids & bases. Mechanisms to perform acid/base balance by the kidney: excrete excess h, reabsorb filtered hco3- (no problem being filtered; kidney ensures this is reabsorbed, create new hco3-