Pharmacology 3620 Lecture Notes - Lecture 6: Androgen-Binding Protein, Ethinyl Estradiol, Luteinizing Hormone

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Endocrine pharm: lecture 6 drugs used to manipulate ferility. The neuroendocrine system is controlled by the hypothalamus and pituitary gland. Gonadotropin releasing hormone (gnrh) acts on cells of the anterior pituitary leading to the producion of luteinizing hormone (lh) and follicle simulaing hormone (fsh) Fsh and lh act on cells of the ovaries and testes to simulate the producion of sex hormones. Simulaion of the hypothalamic-pituitary-gonadal axis results in the secreion of sex hormones: hypothalamus secretes gnrh into the hypophyseal portal system in a pulsaile patern, gnrh simulates gonadotrophic cells of the anterior pituitary to synthesize and secrete lh and. Hypothalamus pituitary: lh and fsh estrogen / testosterone negaive feedback to the hypothalamus estrogen release at ovulaion. Lh and fsh act on two-cell systems in the gonads: ovaries (follicles, testes. Lh and fsh bind to their respecive receptors. Lh binding increases androgen synthesis (in thecal cells) Fsh binding causes the producion of estrogen (via aromatase) (in granulosa cells)

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