Pharmacology 3620 Lecture Notes - Lecture 36: Hypotension, Tachycardia, Subcutaneous Injection

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 3620
• Professor: Rommel Tirona

Document Summary

Drugs for type 1 diabetes mellitus, whether cells use glucose versus fatty acids to generate atp, depends on whether its fed versus fasted state, respectively. If blood glucose is high: glucose will generate atp in most tissues, excess will be stored as glycogen in liver & muscle; triglycerides in adipose. Fatty acids are used to generate atp in most tissues. Insulin will inhibit gluconeogenesis for lower plasma glucose. Insulin: a peptide hormone synthesized as a precursor (prohormone) Two dipeptide cleavage sites will be proteolytically cleaved inside beta-cells (signal peptide, and c-chain: but the alpha & beta chains will still be held by disulfide bonds. C peptide is released and excreted by beta cells at the same time as insulin: the concentration of c peptide can be an indicator of beta-cell function. Insulin secretion by beta-cells occurs in response to high glucose: high plasma glucose = high transport of glucose into beta-cell via.