Pharmacology 2060A/B Lecture Notes - Lecture 5: Renal Function, Distal Convoluted Tubule, Renal Blood Flow
15 Feb 2016
School
Department
Course
Professor
Document Summary
To identify the six sites of drug excretion. To explain how the 3 primary mechanisms involved in renal drug excretion occur. To be able to describe the steps in enterohepatic recycling of drugs. To identify three factors affecting pulmonary drug excretion. To appreciate which drugs may be found in breast milk. Drug excretion is the removal of parent drug and drug metabolites from the body. Drug excretion: kidney, bile, lung, breast milk. The kidneys account for the majority of drug excretion. Healthy kidneys serve to limit the duration and intensity of drug effects. Decreased kidney function prolongs the duration of action and intensity of drug effects. Kidney disease at the final stage (end stage) is when dialysis is required at this stage, drug elimination in the urine is almost negligible: doses of many drugs must be reduced for these patients. The nephron is the basic structural and functional unit of the kidney.
