Pharmacology 2060A/B Lecture Notes - Lecture 17: Pyrimidine, Edema, Stomatitis

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Cancer: uncontrolled proliferation of cells, neoplastic: abnormal and uncontrolled cell growth. Cases by age: less common in children, adolescents and ya, more prevalent as we age. Cases by type: males, prostate, colon/rectum, lung, women, breast, lung, colon/rectum. Treatment options: surgery, tumor is removed, radiation, shrink tumors and kill cancer cells, damages dna of both cancerous and non-cancerous cells, chemotherapy, target rapidly dividing cells (i. e. cancerous) Cell cycle: g0- resti(cid:374)g, (cid:272)ells do(cid:374)"t repli(cid:272)ate, g1- cell prepares to synthesize dna, s-phase- cell synthesizes dna, g2- cell prepares for mitosis, m- cell division in process of mitosis. Early detection: detection is usually late (dark blue line, earlier treatment (light blue, surgery and chemo is very effective is possible (green) Solid tumors: respond poorly to chemotherapy, large fraction of cells in resting (g0) state, chemo drugs target proliferating cells. Drug resistance: cells can develop resistance to drugs used during chemotherapy, mechanisms of resistance:

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