Pharmacology 2060A/B Lecture 11: Module+11+Edited+Notes

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The average 65 year old takes 7 medications, significantly more than the average 20 year old. (cid:120) the most common type of drug-drug interaction are those affecting pharmacokinetics (adme). 11. 2 consequences of drug interactions (cid:120) when two drug or more drugs interact there are 3 possible outcomes: Increased effects: + : decreased effects: + , generation of a new effect: + . Increased effects: (cid:120) drug interactions can increase drug effects by either an increase in the therapeutic effect or an increased adverse effect. Increased therapeutic effects (cid:120) ampicillin is an antibiotic that is rapidly inactivated by bacterial enzymes. (cid:120) sulbactam is an inhibitor of the bacterial enzyme that inactivates ampicillin. Ampicillin + sulbactam increased therapeutic activity of ampicillin. Increased adverse effects (cid:120) warfarin is an anticoagulant used to thin the blood. (cid:120) aspirin is an analgesic that also thins the blood.

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