Pharmacology 4620A Lecture Notes - Lecture 5: Glycogen Phosphorylase, G Protein-Coupled Receptor Kinase, Threonine
15 Nov 2018
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Document Summary
Thought that this was the only target at first. Kinases are a class of enzymes that allows for the reversible phosphorylation of protein (critical signalling mechanism) Abnormal protein phosphorylation is a cause or consequence of many human disease. Kinases catalyze the forwards reaction (adding a phosphate) Phosphatase catalyzes the reverse reaction (removing a phosphate) Terminal ( ) group is transferred to a specific amino acid of the acceptor protein or enzyme. Acceptor residue in eukaryotes commonly contains a hydroxyl group in the side chain. Phosphate group has a double negative charge that can be added to the amino acid. Allows it to act as an organizing center through hydrogen bonds. Or causes electrostatic repulsion of the residue. Phosphate groups also has steric bulk so it can act as a blocker. Enzyme crucial in the breakdown of glycogen to glucose. A: active form, phosphorylated at the serine 14. Movement of the serine also moves one of the -helices.
