Pharmacology 4620A Lecture Notes - Lecture 2: Lipid Bilayer, Biotransformation, Partition Coefficient
15 Nov 2018
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Document Summary
Bioavailability: fraction of drug that reaches circulation in an unchanged form (liberation of the drug) Drug reaches central compartments (organs that have heavy blood flow, drug rapidly leaves this area) Free drug concentration depends on several factors. Prodrugs require biotransformation before it is active. Dependent on the properties of the ligand. Protein expressed on the surface of cells, bind to drugs to transport them across the membrane. A ratio of how much of the drug will dissolve in octanol vs water. Drugs are weak acid or bases so that they can cross the lipid bilayer and switch forms so that they are water soluble. Ph at which the non-ionized and ionized forms of a drug are in equilibrium. The metabolism of a drug by the liver, following absorption, but before it reaches systemic circulation. Protein drugs can be administered orally because they will be digested. What rapid onset for administering no to treat angina.
