Pathology 2420A Lecture Notes - Lecture 4: Cell-Mediated Immunity, Antigen-Presenting Cell, Immunity (Medical)
19 Jul 2019
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Document Summary
Immunity is the body"s defense mechanism against foreign invaders. Immunology is the science that examines the structure and function of immune systems. Lysis of targeted cell: coating (opsonization) organism, marking it for destruction, attraction of other immune cells, release of various factors that result in acute inflammation, trigger coagulation system, kinin system, & fibrinolytic system. Limited to antigen cells (dendritic and macrophages), b-cells & activated t-cells. Localized or generalized reaction that occurs immediately after exposure to antigen: reactions include vascular permeability and smooth muscle contraction. Ige/mast cell interaction: release of vasoactive amines (histamine, example asthma, hay fever, bee sting, and peanuts. 2: type ii: antibody-mediated, caused by igg and igm cytotoxic antibodies. Ag/mhc class i complex in virus infected cells (viral hepatitis, type 1 diabetes) Autoimmune disorders: occur due to breakdown of normal processes, two main factors, discrimination of self and non-self-antigens by t cells.
