Pathology 2420A Lecture Notes - Lecture 7: Coronary Artery Disease, Intermittent Claudication, Cardiac Arrhythmia
11 Dec 2017
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Document Summary
Atherosclerosis & its sequelae - key terms: angina pectoris - refers to the chest pain felt when the myocardium (heart muscle) receives an inadequate blood supply. The pain is typically described as a "tight" or "clenching" feeling, and it may often be felt in the left arm as well as the chest. "plaque": atherosclerosis - a disease of large and medium-sized arteries. The pain usually causes the person to limp. Atherosclerosis is a systemic disease affecting large and medium-sized arteries. It is characterized by the formation of atheromas (fibrofatty plaques) which narrow (stenose) the artery lumen, resulting in reduction of blood flow (ischemia) and subsequent damage or necrosis to the "downstream" organs. Complications of atherosclerosis account for more than half of all deaths in the western world. Atherosclerosis begins early in life but usually remains clinically silent until it has progressed to the point where it results in disease. The earliest pathological lesion is called a fatty streak.
