Pathology 3240A Lecture 8: Immunity Notes
29 May 2016
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The immune system is a collection of mechs that protects against disease by identifying and killing pathogens, tumour cells, and microbial toxins o. Immunology: science that examines the struc and func of the immune sys. Recognition: ability to distinguish between normal self, altered (damaged) self, and non- self (foreign material) Specificity: ability to inactivate, destroy offending material without damaging normal tissues in the vicinity. Regulation: immune system is able to control the type, intensity, and duration of the rxn, and can prevent / suppress immune rxn. Amplification: effector (attack) phase of the immune rxn is mediated via multiple pathways acting synergistically. Memory: an ag that led to a primary immune response is remembered so next time the same ag will result in an accel"d rxn (secondary immune response) Exposure leads to immediate maximal response: nonspecific, does not req a prev exposure to an ag o. Adaptive immune system: o o o o. Exposure --> memory: only in jawed vertebrates.
