Medical Sciences 3999A/B/Y Lecture Notes - Lecture 10: Type Iv Collagen, Matrix Metalloproteinase Inhibitor, Heparan Sulfate
2 Feb 2020
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Tropocollagen (collagen molecule): 280 nm long, 1. 5 nm thick; head and a tail. Forming a fibril - tropocollagen align head-tail in overlapping rows. Main amino acids: glycine (33. 5%), proline (12%) and hydroxyproline (10%) Differences in chemical structure results in various types of collagen (27 types) Ecm of ct made of fibres and ground substances. Collagen fibres - made of collagen (type 1, 2, 3, 5, 7, 9, 11, 12, 14) Acidic dyes (eosin), aniline blue, light green in trichrome. Reticular fibres - made of collagen (type 3) Not visible in h&e, but stained with silver salts (argyrophilic) and are. Pas+ --> both are due to high sugar content in the fibre chains. Formed by loosely packed thin fibrils, bound by interfibrillar bridges (composed of proteoglycans and glycoproteins) Synthesized by reticular cells, which is a fibroblast. Thinner than collagen fibres, arranged in branches --> 3d network. Stain with eosin (light) and special dyes (orcein, resorcein-fuchsin)
