Microbiology and Immunology 4300A Lecture Notes - Lecture 3: Nacht Domain, Blau Syndrome, Nod2
22 Dec 2019
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Cytosolic pattern recognition receptors nod like receptors nlrs. Afamilyof proteinscontaining n terminalsignalingdomain andnodwithor without lrr leucinerichrepeat. Standardnomenclature for nlrs is basedon n terminal motifs. Nlrbs have b bir domain: nlrcs have c card domain onlrps have pcpyrin pyd domain. Over200k patientsand 9k newcaseseveryyearin canada the highestincidences in theworld. Genome wide associationstudiesfoundthatnod2mutationslead to a 17 foldincreasein risk forcd. Singlenucleotide polymorphism snp in nod2: crohn"sdiseasemutationinthe lrrmotif. Dothesesnpscause adominantpositive active mutation activephenotype more ofoundthat this was thesensorforpeptidoglycan. Nodidetects d glutamyl mesodiamino pimelic de g my1 diam p acid i e dap whichisuniqueto gram bacteria. Nop2 detects muramyldipeptide ndp murnac l ala d isogln which is in bothgmm and bacteria signalingcascadeandcellulareffects of nodi12. Rip 2 via card cardinteraction forming the nodosome. Rip 2 is a sennekinasethatwillget poly ubiquitinatedby e3 clap a1 lysine63. Expressionof co stimulatorymoleculesandtap transporterassociated with antigen processing proteins willtrapand kill damagedmitochondria and intracellularmicrobes. Inducestrong tcellactivationbycausingtheexpressionof co receptors cd40and cd80186 andtap112 in. Induceproduction ofinflammatorycytokines tnfx il 6 il 1betc in innateimmunecells.
