Microbiology and Immunology 3820A Lecture Notes - Lecture 6: Rocky Mountain Spotted Fever, Giemsa Stain, Gram Staining
26 Nov 2017
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Historical perspective: named after howard taylor ricketts. Characteristics: like chlamydia, rickettsiae are obligate intracellular parasites, originally thought to be viruses, small gram negative shot rods, gram stain poorly: intracellular location make giemsa stain the best choice. Chalmydia have to use our atp: rickettsia prefers (intracellular) ours but can make its own, enter cells by stimulating phagocytosis them. Genera: rickettsia name of over-all group, orientia, ehrlichia, neorickettsia (new rickettsia, araplasma, coxiella. Dived like other bacteria do: spread to adjacent cells by, bursting the host cell (r. prowazeckii, transmigrating across membrane, budding (o. tsutsugamushi, eventually all organ systems involved. Typhus group (so weak you cant make any sense: typhus= greek for stupor, r. prowozeckii: epidemic louse-borne typhus, brill-zinsser disease (recurrent typhus), sylvatic typhus, r. typhi: endemic flea borne (murine) typhus, r. canada. Cause of outbreak in ww2 people moved to states in large numbers. Spotted fever group: prototype is rickettsia rickettsii, the causative agent of rocky mountain spotted.
